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Table 3 Comparison of preoperative with postoperative semen parameters within particular clinical categories

From: Preoperative semen quality is superior to the quality shortly after orchiectomy in patients with testicular germ cell tumour – a retrospective study from two centres in Germany

 

ejaculate volume (ml)

total sperm count (n × 10 6 )

progressive motility (%)

motility < 30% & TSC < 39 × 10 6

preoperative

postoperative

preoperative

postoperative

preoperative

postoperative

preoperative

postoperative

(n)

median (Q1; Q3)

(n)

median (Q1; Q3)

p

(n)

median (Q1; Q3)

(n)

median (Q1; Q3)

p

(n)

median (Q1; Q3)

(n)

median (Q1; Q3)

p

(n)

(%)

(n)

(%)

p

age

 < 30 yrs

(71)

3.1 (2.1; 4.1)

(144)

2.0 (2.0; 3.0)

< 0.0001

(71)

70.4 (23; 128.8)

(144)

9.5 (2.3; 40)

< 0.0001

(69)

40 (25; 55.5)

(129)

25 (5; 40)

< 0.0001

(69)

24.6

(129)

46.5

0.0026

 

≥ 30 yrs

(92)

3.0 (2.0; 4.4)

(98)

2.2 (2.0; 3.0)

0.0045

(92)

39.7 (6.7; 125.2)

(98)

20 (2; 55)

0.0016

(88)

40 (25; 49.8)

(92)

14.4 (0; 25)

< 0.0001

(88)

31.8

(92)

57.6

0.0005

 

test for age*time interaction

    

0.3203

    

0.1177

    

0.3474

    

0.8418

histology

seminoma

(92)

3.0 (2.1; 4)

(81)

2.0 (2.0; 3.0)

0.0002

(92)

41.9 (6; 126.5)

(81)

10.0 (2.0; 36.0)

< 0.0001

(89)

39.5 (25; 49)

(77)

12.5 (0; 25)

< 0.0001

(89)

34.8

(77)

62.3

0.0004

 

nonseminoma

(71)

3.0 (2.0; 4.4)

(160)

2 (2; 3)

0.0002

(71)

60 (24; 131.3)

(160)

13.8 (3.0; 50.3)

< 0.0001

(68)

40 (25; 58.3)

(143)

25 (5; 40)

< 0.0001

(68)

20.6

(143)

44.8

0.0007

 

test for histology*time interaction

    

0.7843

    

0.5295

    

0.3697

    

0.9848

clinical stage

CS1

(128)

3.0 (2.0; 4.3)

(130)

2.5 (2.0; 3.0)

0.0002

(128)

56.2 (12.5; 133.2)

(130)

15.0 (2.5; 48.0)

< 0.0001

(123)

40 (25; 51.5)

(123)

25 (4; 40)

< 0.0001

(123)

29.3

(123)

44.7

0.0121

 

> CS1

(30)

3.0 (2.0; 4.0)

(107)

2.0 (2.0; 3.0)

0.0047

(30)

59.9 (21.0; 105.3)

(107)

10.0 (2.0; 40.0)

< 0.0001

(29)

40 (25.0; 48.5)

(94)

20.5 (0; 25)

< 0.0001

(29)

20.7

(94)

76.4

0.0002

 

test for CS*time interaction

    

0.9824

    

0.1885

    

0.1700

    

0.0531

AFP

≤ ULN

(125)

3.0 (2.1; 4.0)

(131)

2.0 (2.0; 3.0)

< 0.0001

(125)

45.0 (12.0; 128.7)

(131)

10 (2; 45)

< 0.0001

(121)

40 (25; 50)

(124)

25 (0; 35)

< 0.0001

(121)

30.6

(124)

51.6

0.0008

 

> ULN

(34)

3.5 (2.0; 4.5)

(65)

2.5 (2.0; 3.0)

0.0507

(34)

72.5 (23.0; 119.2)

(65)

14 (3; 50)

0.0004

(33)

40 (25; 56)

(55)

25 (5; 37.5)

0.0006

(33)

18.2

(55)

56.4

0.0004

 

test for AFP*time interaction

    

0.3158

    

0.9610

    

0.7839

    

0.1382

bHCG

≤ ULN

(89)

3.0 (2.1; 4.6)

(122)

2.5 (2.0; 3.0)

< 0.0001

(89)

40.0 (7.5; 126.6)

(122)

14.0 (2.5; 48.0)

< 0.0001

(87)

40 (25; 49.5)

(114)

25 (0.3; 33)

< 0.0001

(87)

29.9

(114)

52.6

0.0012

 

> ULN

(70)

3.0 (2.0; 4.0)

(76)

2.0 (2.0; 3.0)

0.0032

(70)

66.4 (21.0; 128.4)

(76)

7.8 (2.0; 48.0)

< 0.0001

(67)

40 (25; 58)

(67)

25 (0; 40)

< 0.0001

(67)

25.4

(67)

52.2

0.0014

 

test for bHCG*time interaction

0.2024

 

0.4344

 

0.8174

    

0.6601

  1. This analysis shows that the clinical disparities between the two populations (age, histology, CS) are probably not involving an important effect regarding the overall result of better semen quality at preoperative measurements. All subcategories of patients age, histology, clinical stages and tumour marker elevation levels, respectively, uniformly reveal superior semen quality parameters in the preoperative setting. Moreover, the extents of difference (pre- versus postoperative measurement)) between the subgroups (test for time interaction) are not significantly different. Analysis of variance was performed for log (EV), log (TSC) and motility. For binary variables a logistic model was applied to evaluate any potential interaction. CS clinical stage, TSC total sperm count, ULN upper limit of norm, Q1 first quartile, Q3 third quartile, AFP alpha fetoprotein, bHCG beta human chorionic gonadotropin
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Basic and Clinical Andrology

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