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Considered as the most common male sexual problem, premature ejaculation is characterized by the absence of control over the ejaculatory reflex with a correspondingly poor perception of sexual arousal and plea...
Whether varicocoele should be treated while the patient is young remains controversial in spite of the high prevalence of this problem and the fact that it is believed by many to be a causative factor in male ...
During the past decade, various imaging method have been developed which can be used to study the male reproductive tract. Ultrasonography, especially using high frequencies (7.5 or 10 MHz) and transrectal pro...
During the last few years assisted reproductive technology has seen the introduction of oocyte micromanipulation and sperm microinjection as therapeutic approaches for severe male factor infertility. However, ...
Recent experimental studies showed an important role of endothelium derived relaxing factor (EDRF) for cavernous smooth muscle relaxation. Since nitric oxide (NO) seems to account for the biological actions of...
Intracavernosal injections of vaso-active agents were a major breakthrough in the investigation and treatment of impotence. However the first generation agents (papaverine ± phentolamine, phenoxybenzamine) res...
If real priapism is relatively rare, prolonged erection resulting from intracavernous injections is a more and more frequent andrologic emergency. Its diagnosis only rests on physical examination. It requires ...
The sexual problems of the patients with renal failure seem to us a good example of the relationship between sexology and somatic diseases. Multidisciplinary work seems necessary, between somatic physicians, p...
The epidermoid cancer of the male penis is a little frequent tumor. At early stage, the treatment is conservative (curi therapy and laser therapy). At advanced stage the treatment of the primary lesions is amp...
To date only 3 pregnancies have been reported following treatment of emission failure. We report the fourth one obtained from a male with an history of retroperitoneal lymphadenectomy. Pharmacological treatmen...
The structural quality of sperm chromatin of 101 semen samples used in IVF was studied by a simple method. The embryo-cleavage is significantly lower when more than 20% of the spermatozoa show an abnormal chro...
We have examined the IVF results in couples in which the husband had low fructose level as the only abnormal semen parameter. Oocyte cleavage level and pregnancy rate were not different in this group when comp...
A comparative study between three methods of semen analysis reveals that the full automated CMA system gives higher values for sperm concentration than the mean of the three methods, probably due to misclassif...
This is a review of work to define immunosuppressive components of seminal plasma. Much of the work in this text has been undertaken directly or in collaboration by the Department of Surgery, Western General H...
Human prostatic secretion contains only a few major proteins among which one finds albumin, acid phosphatase, prostate specific antigen (PSA), prostatic secretory protein of 94 amino acids (PSP94), Zn-α2-glycopro...
Epithelial cells of mammalian epididymis produced acid and neutral α-glucosidases (α-G) which are either modulated by hormonal systemic influences or by local factors arising from the rete testis fluid. In thi...
The role of the pineal gland and of its main hormone, melatonin, has not yet been clearly defined. The best known activity of the gland is antigonadal, at least in the experimental animals. In fact, the admini...
The current status of the various surgical alternatives in the treatment of impotence is reviewed. Microsurgical techniques for arterial revascularization succeed in 70 to 87% of cases with a mean follow-up of...
Intracavernosal injections of prostaglandin E1 (PGE1) have induced positive erectile responses in 70% of subjects investigated. Mild pain was reported in 15% of cases, with only 5% describing the pain as annoy...
Erectile failure due to veno-occlusive dysfunction (venous incompetence) is generally thought to be resistant to auto-intra-cavernosal injection therapy. Because PGE1 recently emerged as a drug more potent tha...
Doppler investigation play a more and more important role among non invasive investigations to detect penile arterial obstruction because it is simple and costless. However, continuous doppler system gives few...
During the last two years, 381 impotent patients have been tested, 174 with papaverine and 207 with prostaglandin E1 (PGE1: Alprostadil). More positive responses were obtained using PGE1 (76.8%) than papaverin...
The authors report their experience of 414 injections of prostaglandin E1 (prostine). The diagnostic orientation between functional or organic impotence was assessed through questionaires and more particularly...
Intracavernous injection of 20 μg of prostaglandin E1 (PGE1) was carried out in 130 impotent patients. The erectile response was compared to the results of arteriological investigations including nocturnal pen...
Since 1982, many substances have been injected intracavernosally to produce erections in impotent men. Because the first-generation drugs (phenoxybenzamine, papaverine) were associated with severe side-effects...
Prostaglandins (PGs) discovered in 1930 are derived from prostanoic acid and are present in the prostate and seminal vesicles. Every tissue is capable of producing PGs from cell membranes by the action of cycl...
Two of the most common treatments for impotence are compared. While vacuum therapy has been very successful in the United States and other anglo-saxon countries, fear of priapism, fear of injections, and the e...
Sex therapy was born in 1970 with the publication of Masters and Johnson’s landmark book “Human Sexual Inadequacy”. Since then it has evolved under the influences of social changes, medical technological devel...
Treatments usually offered to impotent men include psychotherapy, sex therapy, self-administered intracavernosal injections vacum therapy and penile prostheses. However, these treatments do not meet the expect...
The authors have investigated the electrical activity of corpus cavernous, first according to Wagner and Gerstenberg’ method, then, since one year, according to Stief method, in the basal state and following i...
Investigation of the intracavernosal tissue (ICT) is an important factor in understanding the mechanisms of erection. Histological examination at the ultrastructural level and computerized image analysis are d...
After a long period of general conviction that erectile dysfunction is mostly of psychogenic origin, the introduction of vascular diagnostics into the evaluation of impotence enabled a more refined etiologic a...
This study reports the results of 1080 rigidometry tests performed as the initial investigations on impotent subjects since 1987, comprising 920 visual stimulation tests and 160 nocturnal erection recordings. ...
Although many cases of impotence are associated with “hidden” organic lesions undetectable by normal clinical assessment, and only detectable by paraclinical examination, it is obvious that interactions betwee...
Until recently, the erectile tissues were considered a simple sponge, passively filled or emptied by an imbalance between arterial and venous flows. In reality, the erectile tissues themselves control eretion ...
Two pregnancies have been obtained after assisted procreation using deferential sperm: one by IVF, one by AIC. The indications of this technique are: obstruction of deferens or of ejaculatory ductus, some anej...
The acrosomic status of spermatozoa prepared for IVF has been evaluated by means of immunofluorescence test from Fenichel and Hsi using calcium A 23187 ionophore as inductor of acrosome reaction (AR). The spon...
Basic and Clinical Andrology is the official journal of the French Society of Andrology (SALF).
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Basic and Clinical Andrology